Original Investigation

Role of Menstrual Bleeding Assessments in Sickle Cell Clinics

JAMA Network Open 10.1001/jamanetworkopen.2025.46345

December 09, 2025 at 11:00 AM EST

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What is the association of reproductive health assessment among female patients with sickle cell disease (SCD) and menstrual-related sickle cell pain and hormonal therapies?In this survey study of 211 female patients conducted across 13 US SCD centers, high rates of menstrual-related SCD pain (64.0%) and low rates of contraceptive use (19.2%) were found. In 98.3% of instances, clinicians reported intended clinical actions based on patient survey responses.These findings suggest that menstrual assessments in sickle cell clinics may improve attention and personalized care for female patients with SCD.

Corresponding Author: Neha Bhasin, MD, Division of Hematology, Department of Pediatrics, University of California, San Francisco, 747 52nd St, Oakland, CA 94609 (neha.bhasin@ucsf.edu).

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