Original Investigation

Cognitive Outcomes of Children Exposed to Selective Serotonin Reuptake Inhibitors Through Breast Milk

JAMA Network Open 10.1001/jamanetworkopen.2025.44989

November 21, 2025 at 11:00 AM EST

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Is maternal treatment with selective serotonin reuptake inhibitors (SSRIs) during breastfeeding associated with cognitive performance of the offspring?This cohort study of 97 children who were exposed to maternal treatment with SSRIs during pregnancy with or without exposure during breastfeeding underwent testing with the Wechsler Scales of Preschool and Primary Intelligence. Fully adjusted mean full-scale, verbal, and performance IQ scores were similar among breastfed children exposed to SSRIs, breastfed children not exposed to SSRIs, and nonbreastfed children.These findings suggest that maternal treatment with SSRIs during breastfeeding does not affect the cognitive performance of the offspring.

Corresponding Author: Essi Whaites Heinonen, MD, PhD, Department of Pediatrics, Karolinska Institutet Huddinge, Blickagången 6A, 14157 Huddinge, Sweden (essi.heinonen@ki.se).

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