Parathyroidectomy and Cardiometabolic Risks in Patients With Primary Hyperparathyroidism

Is primary hyperparathyroidism (pHPT) associated with increased cardiometabolic risks, and might parathyroidectomy help reduce these risks?In this cohort study including 50 199 patients with pHPT and 150 265 matched controls, pHPT was associated with significantly increased incidence of hypertension, type 2 diabetes, cardiovascular disease, and cerebrovascular accident. Among 6654 patients with pHPT who underwent parathyroidectomy, the incidence of type 2 diabetes was significantly lower compared with those receiving nonsurgical treatment; no differences were found for other types of cardiometabolic risk.These findings suggest that parathyroidectomy may be associated with reduced risk of type 2 diabetes in patients with pHPT.

Corresponding Author: Nir Tsur, MD, Department of Otolaryngology–Head and Neck Surgery, Rabin Medical Center–Beilinson Hospital, 39 Jabotinsky St, Petach Tikva 4941492, Israel (nirtsur19@gmail.com).

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