Original Investigation

Intubation Trends and Survival in Pediatric In-Hospital Cardiac Arrest

JAMA Network Open 10.1001/jamanetworkopen.2025.44365

November 20, 2025 at 11:00 AM EST

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Should pediatric patients with in-hospital cardiac arrest (IHCA) be intubated during cardiopulmonary resuscitation?In this cohort study of 3262 children who experienced IHCA, rates of intra-arrest intubation decreased across the study period (2000-2022). Using time-dependent propensity-score matched analysis, there was no association between intra-arrest intubation and survival to hospital discharge in a recent (2017-2022) cohort of patients; however, intubation was associated with increased odds of survival to discharge in children aged 8 years or older.Although there was no association between intra-arrest intubation and hospital survival overall, this study’s findings suggest that there are subpopulations of children who may benefit from intra-arrest intubation.

Corresponding Author: Lindsay N. Shepard, MD, MSCE, Division of Critical Care Medicine, Children’s Hospital of Philadelphia, 3401 Civic Center Blvd, 9NW70, Philadelphia, PA 19104 (shepardln@chop.edu).

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