Incidence and Remission of Atopic Dermatitis in a German Birth Cohort

Will children with atopic dermatitis outgrow the disease, and what early-life factors are associated with its remission during the transition to adulthood?In this cohort study with 1314 participants, 87% of participants with atopic dermatitis onset before school age experienced remission by age 30 years. Male children, those with onset after the age of 2 years, and those without specific antibodies to common aero- or food allergens or allergic respiratory symptoms early in life were more likely to become free of symptoms by adulthood.The findings of this study suggest that most children with atopic dermatitis experience symptom resolution by adulthood, with later onset, male sex, and no allergic reactions to common allergens before age 5 years or comorbid allergic conditions being associated with a higher chance of remission.

Corresponding Authors: Thomas Keil, MD, MSc (thomas.keil@charite.de), and Chu-Wei Hung, MPH (chu-wei.hung@charite.de), Institute for Social Medicine, Epidemiology and Health Economics, Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Luisenstr. 57, Berlin D-10117, Germany.

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