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Time to Full Enteral Feeds and Late-Onset Sepsis in Extremely Preterm Infants

JAMA Network Open 10.1001/jamanetworkopen.2025.43940

November 17, 2025 at 11:00 AM EST

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Is there an association between time to full enteral feeding and late-onset sepsis in extremely preterm infants?In this cohort study of 15 102 extremely preterm infants, each additional 1-week delay in achieving full enteral feeding was associated with a 16% higher relative risk of late-onset sepsis in adjusted analyses.These results suggest that delays in establishing full enteral feeding are associated with a higher risk of late-onset sepsis.

Corresponding Author: Ariel A. Salas, MD, MSPH, Department of Pediatrics, University of Alabama at Birmingham, 1700 Sixth Ave S, Women asalas@uab.edu).

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