Transepidermal Water Loss in Oral Food Challenges in Children With Peanut Allergy

Can transepidermal water loss (TEWL) as a measure of skin barrier function be used to reduce anaphylaxis rates and severity during oral food challenges in children with peanut allergy?In this randomized clinical trial that included 40 children aged 6 months to 5 years with peanut allergy, the anaphylaxis rate among participants with an allergic reaction during a peanut oral food challenge was lower in the group for which TEWL was used as a stopping criterion (63%) than in the control group (100%).The findings suggest TEWL can augment anaphylaxis prediction during oral food challenges.

Corresponding Author: Charles F. Schuler IV, MD, Division of Allergy and Clinical Immunology, Department of Internal Medicine, University of Michigan, 109 Zina Pitcher Pl, Biomedical Science Research Bldg, Office 4035, Ann Arbor, MI 48109 (schulerc@med.umich.edu).

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