Acute Kidney Injury and Neurodevelopmental Outcomes in Extremely Premature Neonates

Is acute kidney injury (AKI) in extremely premature infants associated with poor neurodevelopmental outcomes?In this secondary analysis of a randomized clinical trial of 660 extremely low gestational age neonates, acute kidney injury in the first 2 weeks after birth was independently associated with death and/or severe neurodevelopmental impairment at 2 years of age after controlling for potential confounders.Results of this study suggest that extremely low gestation in neonates who developed AKI was associated with worse performance on cognitive developmental scores, even when controlling for potential confounders.

Corresponding Author: Mina Hanna, MD, MSc, Division of Neonatology, Department of Pediatrics, University of Kentucky, 800 Rose St, HA1203, Lexington, KY 40536 (mina.hanna@uky.edu).

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