Early Postpartum Glucose Tolerance Reclassification by Gestational Diabetes Subtype

Do subtypes of gestational diabetes (GD) reclassify differently for glucose tolerance at 6 to 9 weeks after delivery?In this cohort study of 1005 women diagnosed with GD, 3 subtypes were defined using the diagnostic oral glucose testing results, as having isolated postload glucose intolerance (GD-P), fasting hyperglycemia (GD-F), or both defects (GD-M). These subtypes exhibited statistically significant graded increases in adjusted prevalence of postpartum prediabetes with GD-P as most favorable profile, GD-F as intermediate, and GD-M as most predisposed to prediabetes.In this study, distinct postpartum prediabetes prevalence rates highlighted GD heterogeneity, calling for tailored early intervention and postpartum screening strategies by subtype.

Corresponding Authors: Julie A. D. Van, PhD, University of Toronto, One King’s College Circle, Room 3352, Toronto, ON M5S 1A8, Canada (julie.van@mail.utoronto.ca); Erica P. Gunderson, PhD, Kaiser Permanente Northern California, 4480 Hacienda Dr, Pleasanton, CA 94588 (erica.gunderson@kp.org).

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