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Analgesic Differences in Males and Females After Third Molar Surgery

JAMA Network Open 10.1001/jamanetworkopen.2025.42467

November 06, 2025 at 11:00 AM EST

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This prespecified subgroup analysis of a randomized clinical trial investigates noninferiority for pain relief, treatment effects, and patient satisfaction for nonopioids vs opioids in male and female patients after impacted mandibular third molar extraction.

Corresponding Author: Janine Fredericks-Younger, DMD, Rutgers School of Dental Medicine, Rutgers University, 110 Bergen St, Room B813, Newark, NJ 07103 (frederja@sdm.rutgers.edu).

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