Kidney Stone History and Survival Outcomes in Upper Tract Urothelial Carcinoma
JAMA Network Open 10.1001/jamanetworkopen.2025.41054November 03, 2025 at 11:00 AM EST
Is a history of urinary tract stones associated with survival outcomes among patients with upper tract urothelial carcinoma (UTUC)?In this cohort study of 3414 patients with UTUC, a history of urinary stones was associated with significantly worse cancer-specific survival and disease-free survival, even after adjusting for confounders using overlap weighting.These findings suggest that patients with UTUC and stone history may represent a high-risk subgroup requiring intensified surveillance and potentially tailored adjuvant therapy.
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