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Liraglutide and Weight Loss Among Suboptimal Responders to Metabolic Bariatric Surgery

JAMA Network Open 10.1001/jamanetworkopen.2025.39848

October 29, 2025 at 11:00 AM EDT

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Does liraglutide improve weight loss for those with a suboptimal response to metabolic bariatric surgery?In this randomized clinical trial that included 48 adults, the group treated with liraglutide had a mean total body weight loss of 4.4% at 12 months vs a body weight increase of 1.4% in the control group.These results suggest that obesity management medications, such as liraglutide, may be useful adjuncts for people who have had a suboptimal weight loss after metabolic bariatric surgery.

Corresponding Author: Wendy A. Brown, PhD, Department of Surgery, Monash University, 99 Commercial Rd, Level 6, The Alfred Centre, Melbourne, VIC 3004, Australia (wendy.brown@monash.edu).

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