Inequities in Neuropsychiatric Outcomes After Brain Trauma in the All of Us Database

What is the association of neuropsychiatric diagnosis incidence following traumatic brain injury (TBI) with racial disparities?In a cohort study of 8714 participants with a history of TBI in the National Institutes of Health All of Us database, White participants were less likely than Black or African American participants to be diagnosed with psychotic, posttraumatic stress, substance use, or headache disorders. Accounting for sample selection bias, White participants had a lower probability of being diagnosed with psychotic or headache disorders.These findings suggest that there are substantial racial disparities in neuropsychiatric outcomes following TBI, underscoring the importance of accounting for psychosocial and environmental modifiers that may alter TBI outcome trajectories.

Corresponding Author: Tim B. Bigdeli, PhD, SUNY Downstate Health Sciences University, 450 Clarkson Ave, MSC 1203, Public Health Academic Bldg, Brooklyn, NY 11203 (tim.bigdeli@downstate.edu); Ernest J. Barthélemy, MD, MPH, MA, SUNY Downstate Health Sciences University, 450 Clarkson Avenue, MSC B7-343, Brooklyn, NY 11203 (ernest.barthelemy@downstate.edu).

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