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Original Investigation

Cardiovascular Risk Through Hypoxic Burden in Children With Sleep Apnea

JAMA Network Open 10.1001/jamanetworkopen.2025.38744

October 23, 2025 at 11:00 AM EDT

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Does hypoxic burden correlate with nocturnal blood pressure and the nondipping pattern in pediatric obstructive sleep apnea (OSA)?In this secondary analysis of a nonrandomized clinical trial that included 190 children with suspected OSA, elevated values of hypoxic burden were associated with a reduced decrease of nocturnal blood pressure and an increased risk of a nondipping pattern.These findings suggest that hypoxic burden may be a potential marker of cardiovascular risk in the pediatric population with OSA.

Corresponding Author: Olga Mediano, PhD, Hospital Universitario de Guadalajara, Calle Donantes de Sangre, sn, 19002, Guadalajara, Spain (olgamediano@hotmail.com).

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