Genetic Liabilities to Neuropsychiatric Conditions in Suicide Deaths With No Prior Suicidality

Do underlying genetic liabilities associated with neuropsychiatric conditions in suicide deaths without evidence of prior suicidality differ from liabilities in suicide deaths with prior suicidality?This cohort study involving 2769 suicide deaths found that persons in the cohort without prior suicidality showed significantly lower polygenic liabilities associated with neuropsychiatric conditions, mirroring previous clinical results.Differences in underlying genetic liabilities in suicide deaths without prior suicidality suggest a departure from the traditional assumption that neuropsychiatric traits form a sole central core of suicide mortality risk and impel new directions for future research and prevention efforts.

Corresponding Author: Hilary Coon, PhD, Department of Psychiatry, University of Utah, 20 S 2030 East, BPRB Room 408, Salt Lake City, UT 84112 (hilary.coon@utah.edu).

Link to the article in your story

We encourage you to link out to this article in your story using the link below. It includes an access token that will give free access to the article for your readers up to one year after publication. (The link will be live after the article publishes and embargo is lifted.)

Please see the article for additional information, including full author list, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

Need more information? Contact us.