Brain Frailty and Functional Outcomes After Thrombolysis for Acute Ischemic Stroke

Are neuroimaging markers of brain frailty associated with functional outcomes in patients with acute ischemic stroke (AIS) treated with intravenous thrombolysis?In this cohort study of 1568 patients with AIS, the severity of white matter changes, cortical atrophy, and a total brain frailty score capturing the aggregate burden were each associated with worse functional outcomes at 90 days.These findings suggest that brain frailty assessment on baseline neuroimaging using clinical rating scales provides prognostic information for clinicians and patients regarding functional outcomes after reperfusion therapies for AIS, including intravenous thrombolysis with alteplase or tenecteplase.

Corresponding Author: Aravind Ganesh, MD, DPhil(Oxon), Health and Medical Research Building, Room 103, 3280 Hospital Dr NW, Calgary, AB T2N 4Z6, Canada (aganesh@ucalgary.ca).

Link to the article in your story

We encourage you to link out to this article in your story using the link below. It includes an access token that will give free access to the article for your readers up to one year after publication. (The link will be live after the article publishes and embargo is lifted.)

Please see the article for additional information, including full author list, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

Need more information? Contact us.