Original Investigation

Telestroke and Timely Treatment and Outcomes in Patients With Acute Ischemic Stroke

JAMA Network Open 10.1001/jamanetworkopen.2025.34275

September 26, 2025 at 11:00 AM EDT

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How do treatment times and stroke outcomes in patients with acute ischemic stroke evaluated by telestroke compare with those not evaluated by telestroke?In this cohort study of 3036 patients with acute ischemic stroke potentially eligible for thrombolysis, telestroke was associated with a higher odds of receiving thrombolysis, but significantly prolonged door-to-needle and door-in-door-out times and a lower odds of meeting guideline-concordant door-to-needle times within 60 minutes, compared with nontelestroke.These findings suggest that there is room to improve timely stroke treatment for patients evaluated by telestroke to ensure that all patients with ischemic stroke receive guideline-concordant, time-sensitive care.

Corresponding Author: Brian Stamm, MD, MSc, Department of Neurology, Institute for Health Care Policy and Innovation, University of Michigan, 2800 Plymouth Rd, Bldg 16, Room 471C, Ann Arbor, MI 48109 (bstamm@med.umich.edu).

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