Original Investigation

Adherence to American Cancer Society Guideline and Mortality in Men With Nonmetastatic Prostate Cancer

JAMA Network Open 10.1001/jamanetworkopen.2025.33922

September 26, 2025 at 11:00 AM EDT

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Is adherence to the American Cancer Society (ACS) Nutrition and Physical Activity Guideline for Cancer Survivors after a prostate cancer diagnosis associated with lower mortality risk?In this cohort study of 4232 men with nonmetastatic prostate cancer, higher ACS guideline concordance after diagnosis was associated with a 23% lower risk of all-cause mortality and a 25% lower risk of cardiovascular disease mortality; both results were statistically significant. Patients who improved their concordance after diagnosis experienced meaningful reductions in mortality risks.These findings suggest that following the ACS guideline may reduce risk of mortality in men with nonmetastatic prostate cancer, highlighting the importance of lifestyle interventions during survivorship care.

Corresponding Author: Ying Wang, PhD, MS, Department of Population Science, American Cancer Society Inc, 270 Peachtree St NW, Ste 1300, Atlanta, GA 30303 (ying.wang@cancer.org).

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