Original Investigation

Opioid Administration and Reduction of Pediatric Ileocolic Intussusception

JAMA Network Open 10.1001/jamanetworkopen.2025.33584

September 24, 2025 at 11:00 AM EDT

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Is there an association between fentanyl administration and failed intussusception reduction in children?In this cross-sectional study of 3184 children with ileocolic intussusception, fentanyl administration was not associated with failed reduction, but preexisting gastrointestinal anomalies, longer triage to reduction time, and younger age were associated.Findings suggest that fentanyl may be considered a safe option to manage children’s intussusception and subsequent reduction-related pain.

Corresponding Author: Naveen Poonai, MSc, MD, Department of Pediatrics and Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Western University, London, Ontario, 800 Commissioners Rd E, London, ON N6A 2V5, Canada (naveen.poonai@lhsc.on.ca).

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