Original Investigation

Age, Sex, BMI, Meal Timing, and Glycemic Response to Meal Glycemic Load

JAMA Network Open 10.1001/jamanetworkopen.2025.33193

September 23, 2025 at 11:00 AM EDT

Read the full article

Are the glycemic load of mixed meals, age, sex, body mass index (BMI), and meal timing associated with postprandial glucose responses in individuals without diabetes?In this cross-sectional study of 514 adults without diabetes, meals with higher glycemic load were associated with sustained blood glucose elevation, particularly after lunch and dinner. Age notably modified curves of glucose levels after meals, whereas greater BMI was associated with higher and male sex with lower postprandial glucose levels.These findings suggest that glycemic load is associated with postprandial glucose response in the general population of adults without diabetes, accounting for meal timing, age, sex, and BMI.

Corresponding Author: Mar Calvo-Malvar, PhD, Department of Laboratory Medicine, University Clinical Hospital of Santiago de Compostela, Tr Choupana s/n, 15706, Santiago de Compostela, Spain (mariadelmar.calvo.malvar@sergas.es).

Link to the article in your story

We encourage you to link out to this article in your story using the link below. It includes an access token that will give free access to the article for your readers up to one year after publication. (The link will be live after the article publishes and embargo is lifted.)

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.33193?utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_term=092325

Please see the article for additional information, including full author list, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

Need more information? Contact us.

Editor's Picks