Modification of Brain Connectome on Association Between Adverse Childhood Experiences and Development of Mental Disorders in Preadolescence

Does whole-brain functional connectivity modify the association between childhood adversity and psychiatric disorders during the transition to adolescence?In this cohort study of 6813 youths, a machine learning–based connectome variate score derived from baseline resting-state functional magnetic resonance imaging (rsfMRI) data was found to modify the concurrent and prospective associations between exposure to adverse childhood experiences (ACEs) and number of psychiatric disorders at baseline and follow-up assessments.These findings provide preliminary evidence that suggest a whole-brain functional connectivity score derived from rsfMRI data may serve as a neural marker of resilience against ACE-related psychopathology during early adolescence.

Corresponding Author: Yihong Yang, PhD, Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224 (yihongyang@intra.nida.nih.gov).

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