Original Investigation

Label Statements and Perceived Health Benefits of Dietary Supplements

JAMA Network Open 10.1001/jamanetworkopen.2025.33118

September 22, 2025 at 11:00 AM EDT

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Do statements on nutritional supplement labels affect how consumers perceive the supplement’s health benefits?In this survey study, 4403 US adults were randomized to see different labels for fish oil and a nonexistent, hypothetical supplement. For both supplements, participants who viewed labels with statements such as “heart health” or “brain health” were more likely to report believing that the supplement prevented or treated cardiac- and neurologic-related conditions.In this study, consumers were more likely to report specific disease-related health benefits from supplements when their labels included commonly used statements that exceed the scope of their intended meaning, supporting the need to reevaluate regulations regarding nutritional supplement labeling.

Corresponding Author: Ann Marie Navar, MD, PhD, MSc, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, E7.522, Dallas, TX 75201 (ann.navar@utsouthwestern.edu).

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