Efficacy and Safety of Ammoxetine in Major Depressive Disorder

Is ammoxetine safe and effective for treating major depressive disorder (MDD)?In this randomized clinical trial in 239 adult patients with MDD, both ammoxetine 40 mg/d and 60 mg/d significantly decreased the total score of the Montgomery-Åsberg Depression Rating Scale from baseline to week 8 compared with placebo. The incidence and nature of adverse events were similar among groups.These findings support the safety and efficacy of ammoxetine in the treatment of MDD, providing a basis for phase 3 validation.

Corresponding Author: Huafang Li, MD, Department of Psychiatry, Shanghai Mental Health Center, No. 600 Wan Ping S Rd, Shanghai 200030, China (lihuafang@smhc.org.cn).

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