Original Investigation

Antioxidant Treatment and the Chance to Conceive in Men Seeking Fertility Care

JAMA Network Open 10.1001/jamanetworkopen.2025.32405

September 25, 2025 at 11:00 AM EDT

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What is the effect of an antioxidant supplement on male fertility?In this randomized clinical trial including 1171 men seeking fertility care, the ongoing pregnancy rate achieved in men treated with the antioxidant supplement compared with men treated with a placebo was not significantly different.In this trial, treatment of these patients using the antioxidant supplement did not improve pregnancy rates in their female partners.

Corresponding Author: Wiep R. de Ligny, MD, Department of Obstetrics and Gynecology, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, the Netherlands (wiep.deligny@radboudumc.nl).

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