Original Investigation

Antithrombotic Medications and Intraocular Hemorrhage Risk in Exudative Age-Related Macular Degeneration

JAMA Network Open 10.1001/jamanetworkopen.2025.31366

September 11, 2025 at 11:00 AM EDT

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Is the use of anticoagulants or antiplatelets associated with intraocular hemorrhage in age-related macular degeneration?In this cohort study of 149 620 patients with exudative age-related macular degeneration, the use of anticoagulants or antiplatelets was associated with intraocular hemorrhage requiring vitrectomy. The highest risk was observed with the combination of anticoagulants and antiplatelets, and high medication adherence was associated with increased odds of hemorrhage.These findings suggest that patients with age-related macular degeneration should receive proactive communication and monitoring to minimize the threat of intraocular hemorrhage.

Corresponding Author: Se Joon Woo, MD, PhD, Department of Ophthalmology, Seoul National University Bundang Hospital, 173-82 Gumi-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13620, South Korea (sejoon1@snu.ac.kr).

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