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Personalized High-Definition Transcranial Direct Current Stimulation for the Treatment of Depression

JAMA Network Open 10.1001/jamanetworkopen.2025.31189

September 11, 2025 at 11:00 AM EDT

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Is high-definition transcranial direct current stimulation (HD-tDCS) a viable treatment for major depression?In this randomized clinical trial of 71 participants with moderate to severe depression, statistically significant mood improvement was observed in the group who received active HD-tDCS therapy for 12 consecutive working days, relative to a control group who received sham HD-tDCS therapy.HD-tDCS may provide an effective and fast-acting alternative treatment for depression, pending replication and characterization of long-term effects and neural mechanisms.

Corresponding Author: Mayank A. Jog, PhD, UCLA Brain Mapping Center, 660 Charles E Young Drive South, Los Angeles, CA 90095 (mjog@mednet.ucla.edu).

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