Breastfeeding, Prepubertal Adiposity, and Development of Precocious Puberty

Is exclusive breastfeeding in early infancy associated with central precocious puberty?In this cohort study of 322 731 children, those who were exclusively breastfed had a lower risk of central precocious puberty than those who were formula- or mixed-fed. This association was mediated by prepubertal adiposity.These findings suggest that feeding practices in early life are associated with pubertal timing both directly and through childhood adiposity.

Corresponding Authors: Yong Joo Kim, MD, PhD (kyjoo@hanyang.ac.kr), and Seung Yang, MD, PhD (jxisfriend@hanyang.ac.kr), Department of Pediatrics, Hanyang University College of Medicine, 222 Wangsimni-ro, Seongdong-gu, Seoul, South Korea.

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