Particulate Constituents and Posttransplant Outcomes Among Kidney Transplant Recipients

Are constituents of particulate matter with a diameter of 2.5 µm or less (PM) associated with adverse posttransplant outcomes among kidney transplant recipients?In this cohort study with 192 587 kidney transplant recipients, exposure to PM mixture was associated with increased risk of delayed graft function, acute rejection, death-censored graft failure, and mortality after transplant. Of all the constituents studied, sulfate, lead, organic carbon, and nickel contributed the largest weights in the observed associations.In this study, exposure to PM and its constituents, particularly sulfate, lead, organic carbon, and nickel, was associated with higher risks of adverse outcomes among kidney transplant recipients.

Corresponding Author: Yijing Feng, MHS, Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA 02115 (yfeng@g.harvard.edu).

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