Original Investigation

Just-in-Time Adaptive Intervention for Smoking Cessation in Low-Income Adults

JAMA Network Open 10.1001/jamanetworkopen.2025.26691

August 14, 2025 at 11:00 AM EDT

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Does a just-in-time adaptive intervention app that messages based on real-time lapse risk improve smoking cessation compared with the National Cancer Institute QuitGuide app among low-income adults?In this randomized clinical trial of 454 adults with low income, a higher percentage of users of the adaptive app achieved biochemically verified smoking abstinence at 26 weeks compared with QuitGuide users. Adaptive app users also used the app more frequently and rated it as more helpful.These findings suggest that personalized, real-time digital interventions may improve smoking cessation among low-income populations, supporting broader adoption of adaptive mobile health tools.

Corresponding Author: Emily T. Hébert, DrPH, University of Oklahoma Health Sciences, 655 Research Pkwy, Ste 400, Oklahoma City, OK 73104 (emily-hebert@ouhsc.edu).

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