Latent Profile Analysis of Childhood Maltreatment and Neural Markers in Depression

Are latent profiles of childhood maltreatment and neural markers of major depressive disorder (MDD) associated with clinical outcomes, including course, symptom severity, and remission, in antidepressant treatment?In this cross-sectional study of 309 individuals with depression, 4 profiles emerged: (1) low maltreatment and high neural volume, (2) low maltreatment and low neural volume, (3) high maltreatment and high neural volume, and (4) high maltreatment and low neural volume with default mode network hypoconnectivity. Profile 4 had the highest years of morbidity and lowest remission by week 16, while profile 3 showed the highest remission rates.These findings underscore the value of identifying profiles of heterogeneity in MDD to inform personalized intervention.

Corresponding Author: Kate L. Harkness, PhD, Department of Psychology, Queen’s University, 62 Arch St, Kingston, ON K7L 3N6, Canada (harkness@queensu.ca).

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