Original Investigation

Initiation of Antiseizure Medications in Patients With Brain Abscess

JAMA Network Open 10.1001/jamanetworkopen.2025.24557

August 01, 2025 at 11:00 AM EDT

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Are antiseizure medications (ASMs) associated with a reduced risk of epilepsy in brain abscess survivors at 90, 135, and 180 days of follow-up?In this cohort study of 572 patients with a brain abscess, there were no statistically significant differences in the probabilities of epilepsy occurrence at 90, 135, and 180 days after initiation of ASMs.The findings suggest that the initiation of ASMs was not associated with reduced epilepsy risk in patients with brain abscess.

Corresponding Author: Victoria M. Nielsen, MPH, Department of Public Health and Health Sciences, Northeastern University, 360 Huntington Ave, Boston, MA 02115 (v.nielsen@northeastern.edu).

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