Interval Colorectal Cancers in a Fecal Immunochemical Test–Based Screening Program

In a fecal immunochemical test (FIT)–based colorectal cancer (CRC) screening program, what are the incidence, CRC-specific mortality, and survival of interval CRC?In this cohort study of 4018 persons with interval CRCs, the high adenoma detection rate (ADR) was associated with lower postcolonoscopy interval CRC incidence and mortality compared with the low-ADR and middle-ADR groups; however, the survival for postcolonoscopy interval CRC was worse in the high-ADR group.The worse survival of postcolonoscopy interval CRC in the high-ADR group suggests a ceiling effect for current colonoscopic techniques and highlights the possible interplay between procedural and biological factors.

Corresponding Author: Han-Mo Chiu, MD, PhD, Department of Internal Medicine, College of Medicine, National Taiwan University, No. 7 Chung-Shan South Rd, Taipei, Taiwan (hanmochiu@ntu.edu.tw).

Link to the article in your story

We encourage you to link out to this article in your story using the link below. It includes an access token that will give free access to the article for your readers up to one year after publication. (The link will be live after the article publishes and embargo is lifted.)

Please see the article for additional information, including full author list, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

Need more information? Contact us.