External Validation of a Multimodal Model for Predicting Outcomes in Preterm Newborns

Can a multimodal prognostic model predict neurodevelopmental outcomes reliably in extremely preterm newborns?In this prognostic study with 104 participants, the model had a performance similar to that for the model development cohort, with an area under the curve of 85.9% for predicting adverse vs favorable outcomes, and indicated a good fit of the model through calibration.These findings suggest this multimodal model constitutes a robust, highly explainable approach for predicting neurodevelopmental outcomes in preterm newborns, providing valuable prognostic information to guide management decisions within the first 14 days after birth.

Corresponding Author: Laura Routier, MD, PhD, EFSN Pédiatrique, CHU Amiens-Picardie, 1 rond-point du Professeur Christian Cabrol, 80054 Amiens Cedex, France (laura.routier.leturque@u-picardie.fr).

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