Original Investigation

Electronic Health Record Interventions to Reduce Risk of Hospital Readmissions

JAMA Network Open 10.1001/jamanetworkopen.2025.21785

July 17, 2025 at 11:00 AM EDT

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Are electronic health record (EHR)–based interventions associated with reduced risk of hospital readmissions?This systematic review and meta-analysis of 116 randomized clinical trials with 204 523 participants found that EHR-based interventions were associated with reduced risk of 30-day and 90-day all-cause readmission by 17% and 28%, respectively.These findings highlight the potential for leveraging EHR systems to improve patient and health system outcomes, but further research is required to understand which components of EHR interventions drive their effectiveness and for whom.

Corresponding Author: Tyrone G. Harrison, MD, PhD, Department of Medicine, Cumming School of Medicine, University of Calgary, Health Research Innovation Centre, 3230 Hospital Dr NW, Room 2AC58, Calgary, AB T2N 4Z6, Canada (tgharris(@ucalgary.ca).

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