Original Investigation

Fasting Duration and Differences Across Routine Laboratory Tests

JAMA Internal Medicine 10.1001/jamainternmed.2026.4718

September 28, 2026 at 11:00 AM EDT

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This cross-sectional study found that fasting duration was associated with differences exceeding analytical performance specifications for only a few analytes, mainly glucose, triglycerides, γ-glutamyl transferase, and lipase. No estimable within-person difference between the 8- to 12-hour and more than 12-hour groups exceeded an available APS. These findings support analyte-specific rather than uniform fasting requirements.

Corresponding Author: Sollip Kim, MD, PhD, Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Institute of Digital Healthcare, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea (sollip_kim@amc.seoul.kr).

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