Deprescribing Intervention and Reduction of Proton Pump Inhibitor Use in Primary Care

Is a patient- and general practitioner (GP)–facing deprescribing intervention implemented at the health care system scale effective in reducing potentially inappropriate proton pump inhibitor (PPI) use?In this cluster-randomized clinical trial that included 34 409 patients from 683 general practices, a patient- and GP-facing PPI deprescribing intervention significantly reduced PPI use at 1 year compared with usual care (14.9% vs 7.0%) and compared with a GP-facing PPI deprescribing intervention (14.9% vs 7.7%).These findings suggest that among patients with potentially inappropriate PPI use, a patient- and GP-facing PPI deprescribing intervention effectiveness appears to derive its effect primarily from the patient-facing component.

Corresponding Author: Jean-Pascal Fournier, MD, PhD, Département de Médecine Générale, Faculté de Médecine, Nantes Université, 1 rue Gaston Veil, Nantes 44035, France (jean-pascal.fournier@univ-nantes.fr).

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