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Teachable Moment

Rapid Methadone Titration for Opioid Withdrawal Management

JAMA Internal Medicine 10.1001/jamainternmed.2026.0354

April 06, 2026 at 11:00 AM EDT

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This Teachable Moment describes how traditional titration protocols for patients with fentanyl use disorder may be inadequate for patients with frequent, high-dose, or high-potency opioid use.

Corresponding Author: William C. Oles, MD, Department of Medicine, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA 94143 (william.oles@ucsf.edu).

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