Review

Management of Orthostatic Hypotension

JAMA Internal Medicine 10.1001/jamainternmed.2026.0284

April 06, 2026 at 11:00 AM EDT

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All patients with orthostatic symptoms—along with other select patient groups—should be evaluated for orthostatic hypotension. Nonpharmacological treatments are first line, and medication decisions should be tailored based on clinical presentation and relevant comorbidities.

Corresponding Author: Luis E. Okamoto, MD, Vanderbilt Autonomic Dysfunction Center, Division of Genetic Medicine and Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, 1161 21st Ave S, Suite S3120A MCN, Nashville, TN 37232-2600 (luis.e.okamoto@vumc.org).

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