Viewpoint

Remove Oral Diphenhydramine From OTC—End the Status Quo

JAMA Internal Medicine 10.1001/jamainternmed.2025.7278

January 20, 2026 at 11:00 AM EST

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This Viewpoint describes adverse events associated with diphenhydramine and advocates for its withdrawal from over-the-counter (OTC) allergy medications.

Corresponding Author: James H. Clark, MD, Department of Otolaryngology–Head and Neck Surgery, The Johns Hopkins School of Medicine, 601 N Caroline St, Baltimore, MD 21287 (jclark79@jh.edu).

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