Original Investigation

Oral Corticosteroid Use During Pregnancy and the Risk of Gestational Diabetes

JAMA Internal Medicine 10.1001/jamainternmed.2025.6367

December 01, 2025 at 11:00 AM EST

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Does oral corticosteroid use during pregnancy increase the risk of gestational diabetes?In this cohort study of 1 325 940 pregnancies resulting in live births, oral corticosteroid use between 1 and 27 weeks’ gestation was not associated with an increased risk of gestational diabetes compared with unexposed pregnancies.These results suggest that oral corticosteroid treatment during pregnancy does not elevate the risk of gestational diabetes and may be considered a reasonable therapeutic option for managing maternal conditions.

Corresponding Author: Ju-Young Shin, PhD, School of Pharmacy, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do 16419, South Korea (shin.jy@skku.edu).

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