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Clinical Trials Affected by Research Grant Terminations at the National Institutes of Health

JAMA Internal Medicine 10.1001/jamainternmed.2025.6088

November 17, 2025 at 11:00 AM EST

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This cross-sectional study summarizes the number of trials with terminated grants from the National Institutes of Health (NIH) and calculates the proportion of affected trials among those with previously active NIH funding, by trial status at time of grant termination and by trial characteristics.

Corresponding Author: Anupam B. Jena, MD, PhD, Department of Health Care Policy, Harvard Medical School, 180 Longwood Ave, Boston, MA 02115 (jena@hcp.med.harvard.edu).

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