Sex Differences in Mortality and Receipt of Kidney Replacement Therapy Among Adults With Stage 5 Chronic Kidney Disease

Does the female survival advantage observed in the general population persist among adults with stage 5 chronic kidney disease (CKD)?In this cohort study of 7506 adults with incident stage 5 CKD in Alberta, Canada, female individuals were older at disease onset than male individuals. In analyses stratified by age and comorbidities, female individuals younger than 55 years were less likely to survive or receive a kidney transplant than male individuals; female individuals older than 65 years had similar survival but were less likely to receive dialysis.Female individuals may no longer outlive male individuals after developing stage 5 CKD, and their worse outcomes at younger ages warrant further investigation.

Corresponding Author: Ping Liu, PhD, Departments of Medicine and Community Health Sciences, Cumming School of Medicine, University of Calgary, 3230 Hospital Dr NW, Calgary, AB T2N 4Z6, Canada (ping.liu1@ucalgary.ca).

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