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Research Letter

Durability of 2024-2025 COVID-19 Vaccines Against JN.1 Subvariants

JAMA Internal Medicine 10.1001/jamainternmed.2025.5465

October 27, 2025 at 11:00 AM EDT

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This study assesses the durability of protection provided by updated COVID-19 vaccines over a 7-month period, during which circulating SARS-CoV-2 variants were predominantly JN.1 descendants.

Corresponding Author: Dan-Yu Lin, PhD, Department of Biostatistics, University of North Carolina at Chapel Hill, 3101E McGavran-Greenberg Hall, Chapel Hill, NC 27599-7420 (lin@bios.unc.edu).

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