Original Investigation

Slow-Tempo Music and Delirium/Coma-Free Days Among Older Adults Undergoing Mechanical Ventilation

JAMA Internal Medicine 10.1001/jamainternmed.2025.5263

October 13, 2025 at 11:00 AM EDT

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Among critically ill, mechanically ventilated older adults in the intensive care unit, does a music-listening intervention reduce delirium, pain, or anxiety?In this randomized clinical trial of 158 mechanically ventilated older adults, a twice-daily music intervention delivered via noise-canceling headphones and tablets for up to 7 days did not demonstrate a statistically significant decrease in delirium duration, delirium severity, pain, or anxiety.A music-listening intervention did not improve delirium, pain, or anxiety among critically ill older adults.

Corresponding Author: Babar A. Khan, MD, MS, Indiana University School of Medicine, 1101 W 10th St, Indianapolis, IN 46202 (bakhan@iu.edu).

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