Review

Targeting MASLD and MASH in the US Hispanic/Latino Population

JAMA Internal Medicine 10.1001/jamainternmed.2025.4769

September 22, 2025 at 11:00 AM EDT

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The prevalence of MASLD and MASH among Hispanic/Latino persons in the US is a significant public health challenge. Addressing this issue requires multifaceted, culturally mindful strategies that target disparities in nutrition, physical activity, genetics, research, and social determinants of health. Clinicians should incorporate routine FIB-4 risk stratification for MASLD in Hispanic/Latino patients with cardiometabolic risk factors to enable early detection and intervention.

Corresponding Author: Sammy Saab, MD, MPH, Pfleger Liver Institute, UCLA Medical Center, 100 Medical Plaza, Ste 700, Los Angeles, CA 90095 (ssaab@mednet.ucla.edu).

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