Original Investigation

Cognitive Behavioral Therapy for Insomnia in People With Chronic Disease

JAMA Internal Medicine 10.1001/jamainternmed.2025.4610

September 22, 2025 at 11:00 AM EDT

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Is cognitive behavioral therapy for insomnia (CBT-I) effective and acceptable for treating insomnia in individuals with chronic disease?This systematic review and meta-analysis of 67 randomized clinical trials including 5232 participants found that CBT-I was significantly associated with improved insomnia severity, sleep efficiency, and sleep onset latency with moderate to large effect sizes. Treatment associations were moderated by a variety of sample, treatment, and methodological factors, and treatment acceptability and satisfaction were high.These findings suggest that CBT-I is an acceptable and efficacious intervention for managing insomnia in chronic disease populations, supporting its use as a first-line treatment across diverse patient groups.

Corresponding Author: Amelia J. Scott, PhD, Department of Psychology, Macquarie University, Talavera Rd, North Ryde, NSW, Australia 2109 (amelia.scott@mq.edu.au).

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