Original Investigation

Proactive Telehealth-Based Sepsis Transition and Recovery Support, Hospital Readmission, and Mortality

JAMA Internal Medicine 10.1001/jamainternmed.2025.3699

August 11, 2025 at 11:00 AM EDT

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Does a multicomponent, navigator-led sepsis transition and recovery (STAR) program reduce 90-day all-cause rehospitalization and death compared with usual care?In this stepped-wedge cluster randomized clinical trial including 3548 patients, 48.2% randomized to the STAR group compared with 48.0% of patients in the usual care group experienced death or rehospitalization within 90 days of discharge, without a significant difference between groups.Among patients with sepsis, a specialized STAR program delivered for 90 days after discharge did not improve the composite of 90-day all-cause readmission and death.

Corresponding Author: Stephanie Parks Taylor, MD, MS, Division of Hospital Medicine, University of Michigan, 1500 E Medical Center Dr, Ann Arbor, MI 48104 (stptay@med.umich.edu).

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