Adolescent Cannabis Use and Risk of Psychotic, Bipolar, Depressive, and Anxiety Disorders
JAMA Health Forum 10.1001/jamahealthforum.2025.6839February 20, 2026 at 11:00 AM EST
Is adolescent cannabis use associated with an increased risk of developing psychiatric disorders by young adulthood?In this cohort study of 463 396 adolescents aged 13 to 17 years who were universally screened for cannabis use, past-year cannabis use was associated with a significantly increased risk of incident psychotic, bipolar, depressive, and anxiety disorders by age 26 years.This study found that adolescent cannabis use is associated with increased risk of psychiatric disorders in adolescence and young adulthood, highlighting the importance of early prevention efforts, effective public health messaging, and policy development to limit youth exposure as cannabis legalization expands.
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