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Trends in Methadone Use for Pain and Opioid Use Disorder Among Medicaid Enrollees

JAMA Health Forum 10.1001/jamahealthforum.2025.5023

November 21, 2025 at 11:00 AM EST

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This cross-sectional study aims to quantify methadone use for opioid use disorder in the Medicaid program and assesses buprenorphine use as a possible shift between medications for opioid use disorder.

Corresponding Author: Yu-Chia (Sam) Hsu, PharmD, PhD, MSc, Center for Real-World Effectiveness and Safety of Therapeutics, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, 423 Guardian Dr, 836 Blockley Hall, Philadelphia, PA 19104 (yu-chia.hsu@pennmedicine.upenn.edu).

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