JAMA Dermatology Clinicopathological Challenge

A Subcutaneous Nodule With a Central Punctum on the ThighA Subcutaneous Nodule With a Central Punctum on the Thigh—CaseA Subcutaneous Nodule With a Central Punctum on the Thigh—Diagnosis

JAMA Dermatology 10.1001/jamadermatol.2026.0141

April 29, 2026 at 11:00 AM EDT

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A man in his 70s presented with a subcutaneous nodule with a central punctum on the left thigh and a dermal keratinizing cyst in continuity with the overlying epidermis. What is your diagnosis?

Corresponding Author: Mitsuhito Ota, MD, PhD, Department of Dermatology, Chitose City Hospital, Hokkou 2, Chitose 066-8550, Japan (ota@med.hokudai.ac.jp).

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